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  9002-975M   CANTHARONE® Plus
   
HIGH POTENCY WART REMOVER FOR DOCTOR USE ONLY
THE ORIGINAL AND MOST EFFECTIVE CANTHARIDIN TREATMENT
  • PLANTAR WARTS
  • RESISTANT & HEAVILY KERATINIZED WARTS

Important:NOT RECOMMENDED FOR CHILDREN UNDER 12 YEARS. TO BE APPLIED ONLY BY A PHYSICIAN. Due to its toxicity and potential for misuse, CANTHARONE® Plus is not recommended for dispensing or prescribing to patients. Poisonous, may be fatal if ingested. For external use only.

Features:
  • Simple office procedure, no special instrument required
  • A selective procedure not randomly destructive
  • Painless application
  • Produces a uniform blistering action
  • Leaves no permanent scars
Description:
CANTHARONE® PLUS is a topical liquid containing 30% salicylic acid, 2% podophyllin BP, 1% cantharidin in a film-forming vehicle containing 0.5% octylphenylpolyethylene glycol, cellosolve, ethocel, collodion, castor oil and acetone. Salicylic acid is a keratolytic. The chemical name is 2-hydroxybenzoic acid. Podophyllin is a caustic. Its major component, podophyllotoxin (up to 60%) is an anti-neoplastic and roentgomimetic. Cantharidin is a vesicant. The chemical name is hexahydro-3a, 7a-dimethyl-4b, 7b-epoxyisobenzofuran-1, 3-dione. (C10H12O4).
INDICATIONS AND USAGE:
CANTHARONE® PLUS is indicated for removal of warts, especially plantar and resistant and heavily keratinized warts. Painless application and the absence of instruments makes it a simple wart treatment procedure. Some pain may occur later. See DOSAGE AND ADMINISTRATION and WARNINGS sections of instructions for use for specific directions for use.
CLINICAL PHARMACOLOGY:
CANTHARONE® PLUS is a mixture of three wart removers. The action of salicylic acid is thought to be due to its keratolytic activity in removing wart virus infected epithelial cells, podophyllin has caustic properties causing destruction of tissue and cantharidin has vesicant properties which are thought to exfoliate the wart tumor. The exact mechanism of each of these agents is not known.
PRODUCT USE
BEFORE USING, PLEASE REVIEW THE WARNING AND CAUTION INFORMATION IN THE PACKAGE
TREATING RESISTENT, HEAVILY KERATINIZED & PLANTAR WART WITH CANTHARONE® PLUS
  • Method A (no curettage): Occasionally, nails must be trimmed to expose subungual warts to medication. Using a pointed wooden applicator stick, apply CANTHARONE® PLUS sparingly (one layer only) to the wart and about 1 to 3 mm margin around the wart. (For large mosaic warts, treat a portion of the wart at a time.) Allow to dry for a few minutes. Cover with a piece of non-porous plastic adhesive tape, e.g. Blenderm®. Instruct patient to keep the tape on for at least four hours (up to 8 hours). Within 24 hours a blister forms which is often painful and inflamed. Have the patient return for observation in one to two weeks. During this period the patient may or may not do periodic soaks as the doctor prefers. Remove necrotic tissue and treat as before if any viable wart tissue remains. Allow tissue to re-epithelialize before re-treatment.
  • Method B (with curettage): Proceed as in Method A except have patient return in one day for curettage. Local anesthesia may be necessary. There are several advantages to this method; treatment with CANTHARONE® PLUS prior to curettage enhances identification of tissue planes, increases separability of wart tissue and re-treatment is rarely necessary. The lesion normally heals completely within one to three weeks. Have the patient return for observation in four weeks.
SUMMARY OF USE
CANTHARONE® AND CANTHARONE® PLUS
  • Both products are very potent, use sparingly. Treatment is at 10 days to 2 week intervals. Delay treatment if inflamed.
  • Both products are to be used under occlusion with a non-porous tape, e.g.Blenderm®, occlude no longer than 8 hours with CANTHARONE® PLUS and 24 hours with CANTHARONE®
  • Note: Tape is not normally used when treating molluscum
  • Sterile puncture of the blister will help relieve discomfort and should be done at the discretion of the physician.
  • Daily soaks are at the discretion of the physician. It is recommended to use a mild anti-bacterial soap until tissue re-epithelializes.
Warning
Cantharone and Cantharone Plus are for physician use only. They should not be dispensed or prescribed for patient administration under any circumstances.

     
   
       
 
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