Pramoxine hydrochloride

This substance is a topical anesthetic and used as an antipruritic. Like other local anesthetics, the drug decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness. The hydrochloride salt form of Pramoxine is water-soluble.